See caption
Illustration showing the resemblance of the eye to eyebright, a plant used to treat eyesight problems
Source: Science Museum

The doctrine of signatures, originally advocated by the Roman naturalist and natural philosopher Pliny, is the observation that the form of a medicinal plant in some way resembles the organ or disease it can be used to treat, an idea that became common during the medieval period.[1] The Swiss physician and alchemist Paracelsus (1493–1541) advocated strongly for the notion, writing that “Nature marks each growth … according to its curative benefit”; the term doctrine of signatures comes from Jakob Böhme’s 1621 book The Signature of All Things. A theological rationalisation was provided by botanists such as William Coles (1626–1662), who believed that God would have wanted to show men what plants would be useful for.[2]

Belief in the doctrine of signatures was very widespread, not only in classical antiquity or medieval Europe: “All American tribes entertain a profound belief in the doctrine of signatures”.[3]

Scientific foundation

The doctrine of signatures is often dismissed as primitive superstition or pseudoscience, but ethnobiologist Badley C. Bennett argues that the theory has been much maligned by modern scholars, who have attempted to provide untestable post hoc explanations for why any given plant is used to treat certain conditions. There is no evidence that an analysis of a plant’s morphological properties ever led to the identification of a disease process for which it might prove to be an effective treatment. Instead, the doctrine is almost certainly best thought of as a useful mnemonic for herbalists, particularly in preliterate societies.[3]

Signatures of selected plants

The concept of signatures is reflected in the common names of many herbs:[3]

Common nameSpeciesSignatureMedical use
aconiteAconitum napelluseye-like fruitocular problems
bloodrootSanguinaria canadensisred-orange latexblood
foxgloveDigitalis purpureaheart-shaped leavescardiac problems
mandrakeThe mandrake (Mandragora officinalis) is one of 2500 species of plants belonging to the Solanaceae family. Its psychoactive effects have been known to physicians since ancient times. Mandragora officinalishuman-shaped rootspanacea
saxifrageSaxifragabreaks rock as it growskidney stones
snakewortAristolochia serpentarialeaf shape resembles a snake’s headsnake bite
stonecropSedum acreleaf shapekidney stones
wild comfreyCynoglossum virginianumfruits cling to skinmemory
willowSalixsupple branchesrheumatic joints



Bennett, B. C. (2007). Doctrine of Signatures: An Explanation of Medical Plant Discovery or Dissemination of Knowledge. Economic Botany, 61(3), 246–255.
Science Museum. (n.d.). Doctrine of Signatures.
Staff writer. (2006). signatures, doctrine of. In E. Knowles (Ed.), Oxford Dictionary of Phrase and Fable (online). Oxford University Press.